This comes from the Late Night Show too. Jimmy Fallon calls it box of lies. Two people take turns describing what's in a box. The person not describing has to guess if they're lying or not.
Boxes filled with zany things. (If you have ideas, put'em in the comments).
How to Play:
Call up two volunteers. Put a screen between them so they can't see what the other person is opening. One person opens a box and either describes what's in it or lies about the contents. The other person has to guess whether they're telling the truth or lying. Afterwards, the roles switch. Award a point to every right guess. Whoever has the most points at the end wins!